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Literature summary for 3.4.21.116 extracted from

  • Campo, N.; Rudner, D.Z.
    A branched pathway governing the activation of a developmental transcription factor by regulated intramembrane proteolysis (2006), Mol. Cell, 23, 25-35.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed as His-tag fusion protein in Escherichia coli BL21(DE3) pLys Bacillus subtilis

Localization

Localization Comment Organism GeneOntology No. Textmining
endospore-forming forespore secreted by the forespore into the intermembrane space between the forespore and the mother cell membrane Bacillus subtilis 42601
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CtpB + H2O Bacillus subtilis activation of CtpB ?
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?
CtpB + H2O Bacillus subtilis PY79 activation of CtpB ?
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?
SpoIVFA + H2O Bacillus subtilis involved in the regulation of sporulation, cleavage of the extracellular domain, essential for sigmaK processing, cleavage of SpoIVFA at multiple sites activates SpoIVFB which is the enzyme for pro-sigmaK processing, activation of SpoIVFB is suggested to result from conformational changes caused by SpoIVFA cleavage cleaved SpoIVFA + extracellular domain peptides of SpoIVFA
-
?
SpoIVFA + H2O Bacillus subtilis PY79 involved in the regulation of sporulation, cleavage of the extracellular domain, essential for sigmaK processing, cleavage of SpoIVFA at multiple sites activates SpoIVFB which is the enzyme for pro-sigmaK processing, activation of SpoIVFB is suggested to result from conformational changes caused by SpoIVFA cleavage cleaved SpoIVFA + extracellular domain peptides of SpoIVFA
-
?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
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Bacillus subtilis PY79
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-
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Purification (Commentary)

Purification (Comment) Organism
recombinant protein using His-tag Bacillus subtilis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CtpB + H2O
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Bacillus subtilis ?
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?
CtpB + H2O activation of CtpB Bacillus subtilis ?
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?
CtpB + H2O
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Bacillus subtilis PY79 ?
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?
CtpB + H2O activation of CtpB Bacillus subtilis PY79 ?
-
?
GFP-SpoIVFA + H2O
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Bacillus subtilis ?
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?
GFP-SpoIVFA + H2O
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Bacillus subtilis PY79 ?
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?
His tagged extracellular domain of SpoIVFA + H2O four cleavage sites identified Bacillus subtilis ?
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?
His tagged extracellular domain of SpoIVFA + H2O four cleavage sites identified Bacillus subtilis PY79 ?
-
?
SpoIVFA + H2O involved in the regulation of sporulation, cleavage of the extracellular domain, essential for sigmaK processing, cleavage of SpoIVFA at multiple sites activates SpoIVFB which is the enzyme for pro-sigmaK processing, activation of SpoIVFB is suggested to result from conformational changes caused by SpoIVFA cleavage Bacillus subtilis cleaved SpoIVFA + extracellular domain peptides of SpoIVFA
-
?
SpoIVFA + H2O involved in the regulation of sporulation, cleavage of the extracellular domain, essential for sigmaK processing, cleavage of SpoIVFA at multiple sites activates SpoIVFB which is the enzyme for pro-sigmaK processing, activation of SpoIVFB is suggested to result from conformational changes caused by SpoIVFA cleavage Bacillus subtilis PY79 cleaved SpoIVFA + extracellular domain peptides of SpoIVFA
-
?

Synonyms

Synonyms Comment Organism
SpoIVB
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Bacillus subtilis