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Literature summary for 3.4.21.116 extracted from
- Substrate requirements for regulated intramembrane proteolysis of Bacillus subtilis pro-sigmaK (2005), J. Bacteriol., 187, 961-971.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| N-terminal cleavage of the pro-form of the sporulation protein sigmaK | enzyme belongs to S2P family of intramembrane-cleaving proteases | Bacillus subtilis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pro-sigmaK + H2O | amino acids 1-117 are required as a minimum for pro-sigmaK to serve as a substrate, amino acids 1-126 are cleaved much more efficiently. Substitution E13K in pro-sigmaK reduces accumulation of substrate and prevents cleavage by enzmye | Bacillus subtilis | sigmaK + 20 amino acid peptide | - |
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