Literature summary for 3.4.21.112 extracted from

Hyrina, A.; Meng, F.; McArthur, S.J.; Eivemark, S.; Nabi, I.R.; Jean, F.
Human subtilisin kexin isozyme-1 (SKI-1)/Site-1 Protease (S1P) regulates cytoplasmic lipid droplet abundance A potential target for indirect-acting anti-dengue virus agents (2017), PLoS ONE, 12, e0174483 .

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Application

Application	Comment	Organism
medicine	S1P is a potential target for indirect-acting pan-serotypic anti-dengue virus agents	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
PF-429242	active-site-directed inhibitor	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Huh-7.5.1 cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	inhibition of S1P enzymatic activity in human hepatoma Huh-7.5.1 cells results in a robust reduction of the numbers of lipid droplets and lipid droplet-positive areas and effectively inhibits infection by dengue virsu DENV. Pre-treatment of Huh-7.5.1 cells with PF-429242 results in a dose-dependent inhibition of DENV and an about 3-log decrease in DENV-2 titer with 20 microM of PF-429242. Post-treatment of DENV-2 infected Huh-7.5.1 cells with PF-429242 does not affect viral RNA abundance, but it does compromise the assembly and/or release of infectious virus particles. PF-429242 antiviral activity is reversed by exogenous oleic acid	Homo sapiens

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Release 2023.1 (January 2023)