Literature summary for 3.4.21.112 extracted from

Patra, D.; DeLassus, E.; Mueller, J.; Abou-Ezzi, G.; Sandell, L.J.
Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice (2018), Biol. Open, 7, bio032094 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
S1P	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	S1P ablation in the osterix lineage results in osteochondrodysplasia and variable degrees of early postnatal scoliosis. Embryonically, Runx2 and osterix expression are normal, but S1P ablation results in a delay in vascular invasion and endochondral bone development. Mice appear normal when born, but by day 7 display pronounced dwarfism with fragile bones that exhibit significantly reduced mineral density, mineral apposition rate, bone formation rate and reduced osteoblasts. Mice suffer from a drastic reduction in bone marrow mesenchymal progenitors and a drastic reduction in hematopoietic lineage-negative, endothelial-negative, CD105+ skeletal stem cells. Bone marrow mesenchymal progenitors are unable to differentiate into osteoblasts in vitro, with no effect on adipogenic differentiation	Mus musculus

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Release 2023.1 (January 2023)