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Literature summary for 3.4.21.112 extracted from

  • Urata, S.; Yun, N.; Pasquato, A.; Paessler, S.; Kunz, S.; de la Torre, J.C.
    Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease (2011), J. Virol., 85, 795-803.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
PF-429242 potent S1P inhibitor both in vitro and in cell-based assays, PF-429242 inhibits S1P-mediated processing of arenavirus arenavirus glycoprotein precursor protein Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Homo sapiens 5783
-
Golgi apparatus
-
Homo sapiens 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Lassa virus glycoprotein precursor protein + H2O Homo sapiens
-
peripheral virion attachment protein GP1 + fusion-active transmembrane protein GP2 Arg-Arg-Leu-Leu + Gly-Thr-Phe ?
lymphocytic choriomeningitis virus glycoprotein precursor protein + H2O Homo sapiens
-
peripheral virion attachment protein GP1 + fusion-active transmembrane protein GP2 Arg-Arg-Leu-Ala + Gly-Thr-Phe ?
succinyl-YISRRLL-7-amido-4-methylcoumarin + H2O Homo sapiens
-
succinyl-YISRRLL + 7-amino-4-methylcoumarin
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Lassa virus glycoprotein precursor protein + H2O
-
Homo sapiens peripheral virion attachment protein GP1 + fusion-active transmembrane protein GP2 Arg-Arg-Leu-Leu + Gly-Thr-Phe ?
lymphocytic choriomeningitis virus glycoprotein precursor protein + H2O
-
Homo sapiens peripheral virion attachment protein GP1 + fusion-active transmembrane protein GP2 Arg-Arg-Leu-Ala + Gly-Thr-Phe ?
succinyl-YISRRLL-7-amido-4-methylcoumarin + H2O
-
Homo sapiens succinyl-YISRRLL + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
S1P
-
Homo sapiens