Application | Comment | Organism |
---|---|---|
medicine | glycoprotein cleavage by S1P is a promising target for the development of novel anti-arenaviral strategies | Cricetulus griseus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | stable cell lines inducibly expressing S1P-adapted alpha1-antitrypsin variants inhibit the proteolytic maturation of glycoprotein GP-C. Introduction of the S1P recognition motifs RRIL and RRLL into the reactive center loop of alpha1-antitrypsin results in abrogation of glycoprotein GP-C processing by endogenous S1P to a similar level observed in S1P-deficient cells. Moreover, S1P-specific alpha1-antitrypsins significantly inhibit replication and spread of a replication-competent recombinant vesicular stomatitis virus expressing the Lassa virus glycoprotein GP as well as authentic Lassa virus | Cricetulus griseus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | Q9Z2A8 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CHO cell | - |
Cricetulus griseus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glycoprotein precursor Gc + H2O | - |
Cricetulus griseus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
convertase site 1 protease | - |
Cricetulus griseus |
S1P | - |
Cricetulus griseus |
General Information | Comment | Organism |
---|---|---|
malfunction | in CHO cells deficient of S1P (termed SRD-12B cells) glycoprotein GP-C processing is abrogated after Lassa virus infection | Cricetulus griseus |