Protein Variants | Comment | Organism |
---|---|---|
additional information | complete silencing of SKI-1/SP1 results in an embryonic lethal phenotype, elimination of about 70-90% of SKI-1/SP1 protein expression in liver results in a drop of ca. 50% in the level of circulating cholesterol and triglycerides, cholesterol and fatty acid biosynthesis in hepatocytes declines by 75%, low density lipoprotein receptor mRNA declines by 50% | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
membrane | - |
Homo sapiens | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
98000 | - |
- |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
- |
- |
Cricetulus griseus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Oryza sativa | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Abz-Asp-Ile-Tyr-Ile-Ser-Arg-Arg-Leu-Leu-Gly-Thr-Phe-Thr-(3-nitro)Tyr-Ala-NH2 + H2O | favored quenched fluorogenic substrate | Homo sapiens | ? | - |
? | |
ATF6 + H2O | i.e. activating transcription factor 6 | Cricetulus griseus | ? | - |
? | |
Crimean Congo hemorrhagic fever virus glycoprotein + H2O | cleavage at RRLL-sites | Homo sapiens | ? | - |
? | |
Lassa virus glycoprotein + H2O | cleavage at RRLL-sites | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SKI-1/S1P | - |
Cricetulus griseus |
SKI-1/S1P | - |
Mus musculus |
SKI-1/S1P | - |
Homo sapiens |
SKI-1/S1P | - |
Rattus norvegicus |
SKI-1/S1P | - |
Arabidopsis thaliana |
SKI-1/S1P | - |
Oryza sativa |
subtilisin kexin-isozyme-1 | - |
Homo sapiens |