Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.112 extracted from

  • Basak, S.; Stewart, N.A.; Chretien, M.; Basak, A.
    Aminoethyl benzenesulfonyl fluoride and its hexapeptide (Ac-VFRSLK) conjugate are both in vitro inhibitors of subtilisin kexin isozyme-1 (2004), FEBS Lett., 573, 186-194.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-(2-aminoethyl benzene)sulfonyl fluoride i.e. AEBSF, competitive Homo sapiens
Ac-VFRSLK-4-(2-aminoethyl benzene)sulfonyl fluoride
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
secreted soluble form of isozyme-1, SK-1, recombinant protein
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Abz-DIYISRRLL-GTFT-Tyx-A + H2O
-
Homo sapiens Abz-DIYISRRLL + GTFT-Tyx-A
-
?

Synonyms

Synonyms Comment Organism
kexin
-
Homo sapiens
SK-1
-
Homo sapiens
subtilisin kexin isozyme-1
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
57.7
-
Ac-VFRSLK-4-(2-aminoethyl benzene)sulfonyl fluoride substrate Abz-DIYISRRLL-GTFT-Tyx-A, 37°C, pH 7.4 Homo sapiens
231
-
4-(2-aminoethyl benzene)sulfonyl fluoride substrate Abz-DIYISRRLL-GTFT-Tyx-A, 37°C, pH 7.4 Homo sapiens