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Literature summary for 3.4.21.112 extracted from

  • DeBose-Boyd, R.A.; Brown, M.S.; Li, W.P.; Nohturfft, A.; Goldstein, J.L.; Espenshade, P.J.
    Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi (1999), Cell, 99, 703-712.
    View publication on PubMed
Search for more literature for 3.4.21.112

Cloned(Commentary)

Cloned (Comment) Organism
truncated from lacking the COOH-terminal membrane anchor, expressed in CHO cells Cricetulus griseus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus cis-and medial-Golgi, but not in the trans-Golgi Cricetulus griseus 5794
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membrane
-
 Cricetulus griseus 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Cricetulus griseus initiates a process by which the active fragments of the SREBPs translocate to the nucleus and activate genes controlling the synthesis and uptake of cholersterol and unsaturated fatty acids in animal cells ?
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 ?

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
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-
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification SP1-A is inactive and undergoes autocatalytic processing, generating an active form S1P-B, which is further cleaved after residue 186 to generate S1P-C Cricetulus griseus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information initiates a process by which the active fragments of the SREBPs translocate to the nucleus and activate genes controlling the synthesis and uptake of cholersterol and unsaturated fatty acids in animal cells Cricetulus griseus ?
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 ?
sterol regulatory element-binding protein + H2O SREBP, cleaves the luminal loop following the tetrapeptide sequence Arg-Xaa-Xaa-Leu Cricetulus griseus ?
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 ?

Synonyms

Synonyms Comment Organism
S1P
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 Cricetulus griseus