Inhibitors | Comment | Organism | Structure |
---|---|---|---|
HAI-1 | inhibitor of matriptase in skin | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HaCaT cell | - |
Homo sapiens | - |
skin | - |
Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
? | x * 74000, matriptase zymogen, SDS-PAGE | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | HAI-1 but not HAI-2 is the prominent inhibitor for prostasin and matriptase in skin. The limited role for HAI-2 in the inhibition of matriptase and prostasin is the result of its primarily intracellular localization in basal and spinous layer keratinocytes, which probably prevents the HAI-2 from interacting with active prostasin or matriptase | Homo sapiens |