Any feedback?
Literature summary for 3.4.21.109 extracted from
- Matriptase cleaves the amyloid-beta peptide 1-42 at Arg-5, Lys-16, and Lys-28 (2019), BMC Res. Notes, 12, 005 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | coexpression of matriptase with amyloid precursor protein APP695 results in site-specific cleavagesof amyloid precursor protein. Replacement of Arg-601 (Arg-5 in Abeta1-42) by Ala in APP695 prevents matriptase cleavage at this site. Overexpression of matriptase in M17 cells results in a significant reduction of the endogenous amyloid precursor protein quantity | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in M17 cell | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid precursor protein + H2O | - |
Homo sapiens | ? | - |
? |  |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
