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Literature summary for 3.4.21.109 extracted from
- Ibuprofen regulates the expression and function of membrane-associated serine proteases prostasin and matriptase (2015), BMC Cancer, 15, 1025 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Ibuprofen | matriptase zymogen is down-regulated in the UROtsa cells by ibuprofen | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| B6Tert-1 cell | normal trophoblast cell line | Homo sapiens | - |
| JIMT-1 cell | breast cancer cell line | Homo sapiens | - |
| UM-UC-5 cell | bladder transitional cell carcinoma cell line | Homo sapiens | - |
| UM-UC-9 cell | bladder transitional cell carcinoma cell line | Homo sapiens | - |
| UROtsa cell | normal bladder urothelial cell line | Homo sapiens | - |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | matriptase zymogen is down-regulated in the UROtsa cells by ibuprofen | up |
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