Inhibitors | Comment | Organism | Structure |
---|---|---|---|
hepatocyte activation inhibitor 1 | HAI-1, inhibition of matriptase | Homo sapiens | |
KNAR | more selective for matriptase compared to matriptase-2 | Homo sapiens | |
LWWR | 2-fold selectivity for matriptase-2 against matriptase | Homo sapiens | |
additional information | peptide inhibitor docking study with matriptase and matriptase-2, overview | Homo sapiens | |
RLSR | - |
Homo sapiens | |
RNPR | more selective for matriptase compared to matriptase-2 | Homo sapiens | |
WCYR | more selective for matriptase compared to matriptase-2 | Homo sapiens | |
WRER | more selective for matriptase compared to matriptase-2 | Homo sapiens | |
YKAR | - |
Homo sapiens | |
YYVR | 13times more selective for matriptase-2 than matriptase | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
proform matriptase + H2O | Homo sapiens | matriptase is expressed as a zymogen and is autocatalytically processed and activated through cleavage at Arg614 within the RQAR614-VVGG activation sequence | mature matriptase | - |
? | |
proform matriptase-2 + H2O | Homo sapiens | matriptase-2 is expressed as zymogen form and undergoes autocatalysis at Arg576 within the PSSR576-IVGG sequence located in the consensus activation site of its pro-domain | mature matriptase | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8IU80 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | Matriptase is expressed in epithelial cells as a zymogen and needs to be activated. It undergoes spontaneous hydrolysis of a peptide bond at the Gly149 in the SEA domain. The protease is then autocatalytically processed and activated through cleavage at Arg614 within the RQAR614-VVGG activation sequence. Matriptase-2 is exclusively expressed in the liver initially under zymogen form. Matriptase-2 undergoes autocatalysis at Arg576 within the PSSR576-IVGG sequence located in the consensus activation site of its pro-domain | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | is expressed in epithelial cells as a zymogen | Homo sapiens | - |
liver | matriptase-2 is exclusively expressed in the liver initially under zymogen form | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Boc-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O | fluorogenic substrate | Homo sapiens | Boc-Gln-Ala-Arg + 7-amino-4-methylcoumarin | - |
? | |
proform matriptase + H2O | matriptase is expressed as a zymogen and is autocatalytically processed and activated through cleavage at Arg614 within the RQAR614-VVGG activation sequence | Homo sapiens | mature matriptase | - |
? | |
proform matriptase-2 + H2O | matriptase-2 is expressed as zymogen form and undergoes autocatalysis at Arg576 within the PSSR576-IVGG sequence located in the consensus activation site of its pro-domain | Homo sapiens | mature matriptase | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matriptase-2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | a mutation in matriptase is implicated in autosomal recessive ichtyosis withhypotrichosis a rare skin disease | Homo sapiens |
physiological function | deregulation of matriptase can lead to various pathologies. Matriptase is thought to be implicated in osteoarthritis by initiating and inducting cartilage destruction | Homo sapiens |