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Literature summary for 3.4.21.109 extracted from

  • Stirnberg, M.; Maurer, E.; Arenz, K.; Babler, A.; Jahnen-Dechent, W.; Guetschow, M.
    Cell surface serine protease matriptase-2 suppresses fetuin-A/AHSG-mediated induction of hepcidin (2015), Biol. Chem., 396, 81-93.
    View publication on PubMed
Search for more literature for 3.4.21.109

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface cell surface type II transmembrane protein Homo sapiens 9986
-
membrane cell surface type II transmembrane protein Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hemojuvelin + H2O Homo sapiens
-
 ?
-
 ?
matriptase-2 + H2O Homo sapiens autocatalysis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8IU80
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fetuin-A + H2O a liver-derived alpha2-Heremans-Schmid glycoprotein from plasma, processing into a two-chain form, cleavage sites are Arg and Lys residues in the 40 amino acid sequence of the linker connceting the two peptides Homo sapiens ?
-
 ?
hemojuvelin + H2O
-
 Homo sapiens ?
-
 ?
matriptase-2 + H2O autocatalysis Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
matriptase-2
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction downregulation of the enzyme stabilizes fetuin-A in the unprocessed form Homo sapiens
physiological function the enzyme controls the expression of hepcidin, the key regulator of iron homeostasis. By cleaving hepcidin, the enzyme supresses bone morphogenetic protein against decapentaplegic signaling Homo sapiens