Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
prostasin + H2O | Mus musculus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | matriptase is detected in the suprabasal epidermis with the highest level of expression in the granular and transitional cell layers | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prostasin + H2O | - |
Mus musculus | ? | - |
? |
General Information | Comment | Organism |
---|---|---|
malfunction | the genetic elimination of matriptase completely abolishes the aberrant caseinolytic activity that is caused by lympho-epithelial Kazal-type-related inhibitor (LEKTI) deficiency in both the lower epidermal layers as well as in the dermis. Matriptase elimination prevents spontaneous stratum corneum loss, restores keratohyalin granules, and improves the barrier function of LEKTI-deficient epidermis. Loss of matriptase restores corneodesmosome integrity to LEKTI-deficient epidermis. Matriptase ablation prevents kallikrein hyperactivity-mediated inflammation caused by LEKTI-deficiency | Mus musculus |
physiological function | matriptase initiates Netherton syndrome in a lympho-epithelial Kazal-type-related inhibitor (LEKTI)-deficient mouse model by premature activation of a pro-kallikrein-related cascade. Matriptase is an efficient activator of epidermal pro-kallikreins that co-localize with LEKTI at the granular-transitional layer boundary | Mus musculus |