Literature summary for 3.4.21.109 extracted from

Lee, S.L.; Huang, P.Y.; Roller, P.; Cho, E.G.; Park, D.; Dickson, R.B.
Matriptase/epithin participates in mammary epithelial cell growth and morphogenesis through HGF activation (2010), Mech. Dev., 127, 82-95.

Search for more literature for 3.4.21.109

Inhibitors

Inhibitors	Comment	Organism	Structure
SFTI1	serine protease inhibitor can only inhibit Epi/MTP and cathepsin G. Mammary epithelial growth and morphogenesis in the presence of the latent form hepatocyte growth factor (pro-HGF) is blocked by addition of SFTI1 an inhibitor of the Epi/MTP protease activity	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
mammary epithelium	Epi/MTP is expressed at low level in the mouse mammary epithelium of young animals and it accumulates at the terminal end-bud of the growing ducts. The level of Epi/MTP is elevated in the mammary glands at stages when epithelial proliferation and modeling occur. It is primarily present in the luminal epithelial cells of mouse mammary ducts and lobules	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
Epi/MTP	-	Mus musculus
epithin/matriptase	-	Mus musculus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00000092	-	SFTI1	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	Epi/MTP is expressed at low level in the mouse mammary epithelium of young animals	down
Mus musculus	level of Epi/MTP is elevated in the mammary glands at stages when epithelial proliferation and modeling occur	up

General Information

General Information	Comment	Organism
malfunction	mammary epithelial growth and morphogenesis in the presence of the latent form hepatocyte growth factor (pro-HGF) is blocked either by addition of SFTI1 an inhibitor of the Epi/MTP protease activity or by siRNA knockdown of the Epi/MTP expression	Mus musculus
physiological function	Epi/MTP participates in mammary epithelial growth and modeling through activation of pro-hepatocyte growth factor	Mus musculus

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Release 2023.1 (January 2023)