Literature summary for 3.4.21.109 extracted from

Miyake, Y.; Tsuzuki, S.; Fushiki, T.; Inouye, K.
Matriptase does not require hepatocyte growth factor activator inhibitor type-1 for activation in an epithelial cell expression model (2010), Biosci. Biotechnol. Biochem., 74, 848-850.

Search for more literature for 3.4.21.109

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	it is shown that hepatocyte growth factor activator inhibitor type-1 is not required for activation of matriptase in stably transfected Madin-Darby canine kidney cells	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
full-length rat matriptase is expressed with a myc-epitope and a hexahistidine tag at its C-terminus in stably transfected Madin-Darby canine kidney cells	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
Aprotinin	-	Rattus norvegicus
hepatocyte growth factor activator inhibitor type-1	-	Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
28000	-	Western blot analysis using conditioned medium, catalytic domain of proteolytically active two-chain matriptase C-terminal fragment	Rattus norvegicus
90000	-	Western blot analysis using conditioned medium, proteolytically inactive single-chain C-terminal fragment	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	matriptase is processed post-translationally via cleavage between Gly149 and Ser150. The C-terminal fragment Ser150-Val855 occurs abundantly in the conditioned medium	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
matriptase	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	hepatocyte growth factor activator inhibitor type-1 is not required for activation of matriptase in stably transfected Madin-Darby canine kidney cells	Rattus norvegicus

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Release 2023.1 (January 2023)