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Literature summary for 3.4.21.109 extracted from

  • Wang, J.; Lee, M.; Tseng, I.; Chou, F.; Chen, Y.; Fulton, A.; Lee, H.; Chen, G.; Johnson, M.; Lin, C.
    Polarized epithelial cells secrete matriptase as a consequence of zymogen activation and HAI-1-mediated inhibition (2009), Am. J. Physiol. Cell Physiol., 297, 459-470.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.109

Inhibitors

Inhibitors Comment Organism Structure
hepatocyte growth factor activator inhibitor active protease is inhibited by, and forms complexes with, hepatocyte growth factor activator inhibitor (HAI-1) Homo sapiens
hepatocyte growth factor activator inhibitor-1 activated matriptase is immediately inhibited by and forms complex with hepatocyte growth factor activator inhibitor-1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
apical plasma membrane a proportion of matriptase-hepatocyte growth factor activator inhibitor-1 complexes, but not the latent matriptase, undergo transcytosis to the apical plasma membrane for secretion Homo sapiens 16324
-
basolateral plasma membrane latent matriptase is localized at the basolateral surface of the ductal epithelial cells of prostate and kidney and in Caco-2 cells. The cells target latent matriptase to the basolateral plasma membrane where activation, inhibition, and secretion of matriptase take place Homo sapiens 16323
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
110
-
 Western blot analysis using seminal fluid, seminal fluid contains only activated matriptase in complex with antithrombin III, supposed 70 kDa active matriptase and a 40 kDa antithrombin III-fragment Homo sapiens
85000
-
 Western blot analysis using seminal fluid, seminal fluid contains only activated matriptase in complex with hepatocyte growth factor activator inhibitor-1 (HAI-1), supposed 70 kDa active matriptase and a 15 kDa HAI-fragment Homo sapiens
95000
-
 Western blot analysis using seminal fluid or urine, seminal fluid or urine contain only activated matriptase in complex with hepatocyte growth factor activator inhibitor-1 (HAI-1), supposed 70 kDa active matriptase and a 25 kDa HAI-fragment Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification matriptase is synthesized as a zymogen and undergoes autoactivation to become an active protease Homo sapiens
proteolytic modification matriptase is synthesized as a zymogen and undergoes autoactivation to become an active protease that is immediately inhibited by, and forms complexes with, hepatocyte growth factor activator inhibitor (HAI-1) Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell cells target latent matriptase to the basolateral plasma membrane where activation, inhibition, and secretion of matriptase take place. A proportion of matriptase-HAI-1 complexes, but not the latent matriptase, undergoes transcytosis to the apical plasma membrane for secretion Homo sapiens
-
Caco-2 cell latent matriptase is localized at the basolateral surface of the ductal epithelial cells of prostate and kidney Homo sapiens
-
kidney latent matriptase is localized at the basolateral plasma membrane of the ductal epithelial cells of the prostate and kidney Homo sapiens
-
kidney latent matriptase is localized at the basolateral surface of the ductal epithelial cells of prostate and kidney Homo sapiens
-
milk contains only activated matriptase Homo sapiens
-
prostate latent matriptase is localized at the basolateral plasma membrane of the ductal epithelial cells of the prostate and kidney Homo sapiens
-
prostate latent matriptase is localized at the basolateral surface of the ductal epithelial cells of prostate and kidney Homo sapiens
-
semen only matriptase-HAI-1 complexes and not latent matriptase are detected in urine and seminal fluid Homo sapiens
-
seminal fluid contains only activated matriptase in complex with hepatocyte growth factor activator inhibitor-1 or antithrombin III but no latent matriptase Homo sapiens
-
urine contains only activated matriptase in complex with hepatocyte growth factor activator inhibitor-1 but no latent matriptase Homo sapiens
-
urine only matriptase-HAI-1 complexes and not latent matriptase are detected in urine and seminal fluid Homo sapiens
-

Synonyms

Synonyms Comment Organism
matriptase
-
 Homo sapiens