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Literature summary for 3.4.21.109 extracted from

  • Silvestri, L.; Pagani, A.; Nai, A.; De Domenico, I.; Kaplan, J.; Camaschella, C.
    The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin (2008), Cell Metab., 8, 502-511.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.109

Cloned(Commentary)

Cloned (Comment) Organism
into the vector pcDNA3.1 Homo sapiens

Protein Variants

Protein Variants Comment Organism
MT2MASK matriptase-2 mutant lacking the serine protease domain Mus musculus
R774C inactive mutant Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-
membrane
-
 Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
 serine protease domain, determined by SDS-PAGE and Western blot analysis Homo sapiens
60000
-
 serine protease domain, dimer, determined by SDS-PAGE and Western blot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hemojuvelin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 anemic Mask mouse
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
HEP-3B cell
-
 Homo sapiens
-
liver
-
 Mus musculus
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hemojuvelin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
serine protease matriptase-2
-
 Mus musculus
serine protease matriptase-2
-
 Homo sapiens
TMPRSS6
-
 Mus musculus
TMPRSS6
-
 Homo sapiens