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Literature summary for 3.4.21.109 extracted from

  • Qiu, D.; Owen, K.; Gray, K.; Bass, R.; Ellis, V.
    Roles and regulation of membrane-associated serine proteases (2007), Biochem. Soc. Trans., 35, 583-587.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information matriptase-deficient mice develop normally, but do not survive postnatally owing to an epidermal barrier defect, transgenic mice with a very modest overexpression of matriptase in the skin become remarkably susceptible to carcinogen-induced tumour formation Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
Homo sapiens 9986
-
plasma membrane matriptase is a type II transmembrane serine protease Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hepatocyte growth factor + H2O Mus musculus proteolytic activation of hepatocyte growth factor/scatter factor, overview activated hepatocyte growth factor + ?
-
?
hepatocyte growth factor + H2O Homo sapiens proteolytic activation of hepatocyte growth factor/scatter factor, physiological function, overview activated hepatocyte growth factor + ?
-
?
additional information Homo sapiens matriptase is a type II transmembrane serine protease and highly regulated in leukocytes, and correlates with the presence of active uPA on their surface, it is up-regulated in a variety of cancers and correlates closely with disease progression, it acts as initiator of protease cascades/signaling pathways, overview ?
-
?
additional information Mus musculus matriptase is a type II transmembrane serine protease, that is up-regulated in a variety of cancers and correlates closely with disease progression, it acts as initiator of protease cascades/signaling pathways, overview ?
-
?
urokinase plasminogen activator + H2O Mus musculus pro-uPA activation urokinase plasminogen activator + propeptide of urokinase plasminogen activator
-
?
urokinase plasminogen activator + H2O Homo sapiens pro-uPA activation on THP-1 cells urokinase plasminogen activator + propeptide of urokinase plasminogen activator
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell matriptase is up-regulated in a variety of cancers and correlates closely with disease progression Mus musculus
-
carcinoma cell matriptase is up-regulated in a variety of cancers and correlates closely with disease progression Homo sapiens
-
leukocyte
-
Homo sapiens
-
skin
-
Mus musculus
-
skin
-
Homo sapiens
-
THP-1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hepatocyte growth factor + H2O
-
Mus musculus activated hepatocyte growth factor + ?
-
?
hepatocyte growth factor + H2O
-
Homo sapiens activated hepatocyte growth factor + ?
-
?
hepatocyte growth factor + H2O proteolytic activation of hepatocyte growth factor/scatter factor, overview Mus musculus activated hepatocyte growth factor + ?
-
?
hepatocyte growth factor + H2O proteolytic activation of hepatocyte growth factor/scatter factor, physiological function, overview Homo sapiens activated hepatocyte growth factor + ?
-
?
additional information matriptase is a type II transmembrane serine protease and highly regulated in leukocytes, and correlates with the presence of active uPA on their surface, it is up-regulated in a variety of cancers and correlates closely with disease progression, it acts as initiator of protease cascades/signaling pathways, overview Homo sapiens ?
-
?
additional information matriptase is a type II transmembrane serine protease, that is up-regulated in a variety of cancers and correlates closely with disease progression, it acts as initiator of protease cascades/signaling pathways, overview Mus musculus ?
-
?
pro-urokinase plasminogen activator + H2O
-
Mus musculus urokinase plasminogen activator + propeptide of urokinase plasminogen activator
-
?
pro-urokinase plasminogen activator + H2O
-
Homo sapiens urokinase plasminogen activator + propeptide of urokinase plasminogen activator
-
?
urokinase plasminogen activator + H2O pro-uPA activation Mus musculus urokinase plasminogen activator + propeptide of urokinase plasminogen activator
-
?
urokinase plasminogen activator + H2O pro-uPA activation on THP-1 cells Homo sapiens urokinase plasminogen activator + propeptide of urokinase plasminogen activator
-
?

Synonyms

Synonyms Comment Organism
More the enzyme belongs to the family of type II transmembrane serine proteases Mus musculus
More the enzyme belongs to the family of type II transmembrane serine proteases Homo sapiens