Protein Variants | Comment | Organism |
---|---|---|
additional information | matriptase-deficient mice develop normally, but do not survive postnatally owing to an epidermal barrier defect, transgenic mice with a very modest overexpression of matriptase in the skin become remarkably susceptible to carcinogen-induced tumour formation | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
plasma membrane | matriptase is a type II transmembrane serine protease | Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hepatocyte growth factor + H2O | Mus musculus | proteolytic activation of hepatocyte growth factor/scatter factor, overview | activated hepatocyte growth factor + ? | - |
? | |
hepatocyte growth factor + H2O | Homo sapiens | proteolytic activation of hepatocyte growth factor/scatter factor, physiological function, overview | activated hepatocyte growth factor + ? | - |
? | |
additional information | Homo sapiens | matriptase is a type II transmembrane serine protease and highly regulated in leukocytes, and correlates with the presence of active uPA on their surface, it is up-regulated in a variety of cancers and correlates closely with disease progression, it acts as initiator of protease cascades/signaling pathways, overview | ? | - |
? | |
additional information | Mus musculus | matriptase is a type II transmembrane serine protease, that is up-regulated in a variety of cancers and correlates closely with disease progression, it acts as initiator of protease cascades/signaling pathways, overview | ? | - |
? | |
urokinase plasminogen activator + H2O | Mus musculus | pro-uPA activation | urokinase plasminogen activator + propeptide of urokinase plasminogen activator | - |
? | |
urokinase plasminogen activator + H2O | Homo sapiens | pro-uPA activation on THP-1 cells | urokinase plasminogen activator + propeptide of urokinase plasminogen activator | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell | matriptase is up-regulated in a variety of cancers and correlates closely with disease progression | Mus musculus | - |
carcinoma cell | matriptase is up-regulated in a variety of cancers and correlates closely with disease progression | Homo sapiens | - |
leukocyte | - |
Homo sapiens | - |
skin | - |
Mus musculus | - |
skin | - |
Homo sapiens | - |
THP-1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hepatocyte growth factor + H2O | - |
Mus musculus | activated hepatocyte growth factor + ? | - |
? | |
hepatocyte growth factor + H2O | - |
Homo sapiens | activated hepatocyte growth factor + ? | - |
? | |
hepatocyte growth factor + H2O | proteolytic activation of hepatocyte growth factor/scatter factor, overview | Mus musculus | activated hepatocyte growth factor + ? | - |
? | |
hepatocyte growth factor + H2O | proteolytic activation of hepatocyte growth factor/scatter factor, physiological function, overview | Homo sapiens | activated hepatocyte growth factor + ? | - |
? | |
additional information | matriptase is a type II transmembrane serine protease and highly regulated in leukocytes, and correlates with the presence of active uPA on their surface, it is up-regulated in a variety of cancers and correlates closely with disease progression, it acts as initiator of protease cascades/signaling pathways, overview | Homo sapiens | ? | - |
? | |
additional information | matriptase is a type II transmembrane serine protease, that is up-regulated in a variety of cancers and correlates closely with disease progression, it acts as initiator of protease cascades/signaling pathways, overview | Mus musculus | ? | - |
? | |
pro-urokinase plasminogen activator + H2O | - |
Mus musculus | urokinase plasminogen activator + propeptide of urokinase plasminogen activator | - |
? | |
pro-urokinase plasminogen activator + H2O | - |
Homo sapiens | urokinase plasminogen activator + propeptide of urokinase plasminogen activator | - |
? | |
urokinase plasminogen activator + H2O | pro-uPA activation | Mus musculus | urokinase plasminogen activator + propeptide of urokinase plasminogen activator | - |
? | |
urokinase plasminogen activator + H2O | pro-uPA activation on THP-1 cells | Homo sapiens | urokinase plasminogen activator + propeptide of urokinase plasminogen activator | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme belongs to the family of type II transmembrane serine proteases | Mus musculus |
More | the enzyme belongs to the family of type II transmembrane serine proteases | Homo sapiens |