Literature summary for 3.4.21.109 extracted from

Lee, M.; Tseng, I.; Wang, Y.; Kiyomiya, K.; Johnson, M.D.; Dickson, R.B.; Lin, C.
Autoactivation of matriptase in vitro: requirement for biomembrane and LDL receptor domain (2007), Am. J. Physiol. Cell Physiol., 293, C95-C105.

Search for more literature for 3.4.21.109

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	the enzyme is induced by lysophospholipids, androgens, and the polyanionic suramin, the agents induce different signaling pathways and cellular events in a cell type-specific manner leading to matriptase activation, which requires an intact lipid bilayer microenvironment, enzyme activation within the range of pH 5.2-7.2, overview, inhibition of matriptase activation in vitro and in vivo, overview	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
anti-matriptase LDL receptor domain 3-specific monoclonal antibodies	complete inhibition of enzyme activation	Homo sapiens
hepatocyte growth factor activator inhibitor-1	HAI-1	Homo sapiens
additional information	inhibition of matriptase activation in vitro and in vivo, overview	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	-	Homo sapiens	5783	-
Golgi membrane	-	Homo sapiens	139	-
membrane	bound	Homo sapiens	16020	-
perinuclear space	-	Homo sapiens	-	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
70000	-	x * 70000, inactive zymogen, SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	matriptase performs autoactivation	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
184A1N4 cell	mammary epithelial cell line	Homo sapiens	-
LNCaP cell	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
T-47D cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	matriptase performs autoactivation	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
?	x * 70000, inactive zymogen, SDS-PAGE	Homo sapiens

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Release 2023.1 (January 2023)