Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | prolonged stabilization of matriptase by GnT-V-mediated glycosylation in vivo, thus extending its half-life and permitting it to play role in the early phases of papillary carcinoma, but not in its later phase progression, overview | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | prolonged stabilization of matripase is stabilized by UDP-N-acetylglucosamine: alpha-mannoside beta-1,6-N-acetylglucosminyltransferase-mediated glycosylation in vivo, thus extending its halftime and permitting it to play role in the early phases of papillary carcinoma, but not in its later progression | Homo sapiens |
General Stability | Organism |
---|---|
prolonged stabilization of matriptase by GnT-V-mediated glycosylation in vivo, thus extending its half-life and permitting it to play role in the early phases of papillary carcinoma, but not in its later phase progression, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | prolonged stabilization of matriptase by GnT-V-mediated glycosylation in vivo, thus extending its half-life and permitting it to play role in the early phases of papillary carcinoma, but not in its later phase progression, overview | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell | the secretion of matriptase from cancer cells is increased via the action of GnT-V, i.e. UDP-N-acetylglucosamine:alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase, overview | Homo sapiens | - |
additional information | not in normal thyroid tissue | Homo sapiens | - |
thyroid cancer cell | 44.1% of papillary carcinomas, 15.4% of follicular adenomas, none follicular or anaplastic carcinomas | Homo sapiens | - |
thyroid cancer cell | co-expression of matriptase and N-acetylglucosaminyltransferase V in thyroid cancer tissues, analysis of expression of GnT-V and matriptase in thyroid neoplasm tissues, papillary carcinoma and follicular carcinoma, overview | Homo sapiens | - |