Activating Compound | Comment | Organism | Structure |
---|---|---|---|
hepatocyte growth factor activator inhibitor-1 | - |
Homo sapiens | |
sphingosine 1-phosphate | mediates translocation of the enzyme to cell-cell junctions, sphingosine 1-phosphate-induced matripase activation is enhancend by reduced hepatocyte growth factor activator inhibitor-1 expression | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | multiple roles for hepatocyte growth factor activator inhibitor-1 to regulate matripase, including its proper expression, intracellular trafficking, activation and inhibition | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
into vector pcDNA3.1, expressed in BT549 breast cancer cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D799A | matripase mutant altered in the substrate binding pocket, is able to traffic in the absence of hepatocyte growth factor activator inhibitor-1 | Homo sapiens |
S805A | matripase mutant altered in the catalytic triad, is able to traffic in the absence of hepatocyte growth factor activator inhibitor-1 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
hepatocyte growth factor activator inhibitor-1 | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
70000 | - |
immunoblotting, latent NH2 terminal processed form matripase | Homo sapiens |
85000 | - |
immunoblotting, full-length hepatocyte growth factor activator inhibitor-1 complexed with the serine protease domain of matripase | Homo sapiens |
93000 | - |
immunoblotting, latent full-length matripase | Homo sapiens |
120000 | - |
immunoblotting, 70000 active matripase plus full-length hepatocyte growth factor activator inhibitor-1 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
184A1N4 cell | proportional increases or decreases in matripase and hepatocyte growth factor activator inhibitor-1 | Homo sapiens | - |