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Literature summary for 3.4.21.109 extracted from

  • Lee, S.L.; Dickson, R.B.; Lin, C.Y.
    Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease (2000), J. Biol. Chem., 275, 36720-36725.
    View publication on PubMed
Search for more literature for 3.4.21.109

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00381
-
 N-tert-butoxycarbonyl-gamma-benzyl-Glu-Ala-Arg-7-amido-4-methylcoumarin pH 8.5 Homo sapiens
0.00489
-
 N-tert-butoxycarbonyl-Gln-Ala-Arg 7-amido-4-methylcoumarin pH 8.5 Homo sapiens
0.0136
-
 N-tert-butoxycarbonyl-Leu-Gly-Arg-7-amido-4-methylcoumarin pH 8.5 Homo sapiens
0.0335
-
 N-tert-butoxycarbonyl-Gln-Ala-Arg 7-amido-4-methylcoumarin pH 8.5 Homo sapiens
0.0475
-
 N-tert-butoxycarbonyl-gamma-benzyl-Glu-Gly-Arg-7-amido-4-methylcoumarin pH 8.5 Homo sapiens
0.0699
-
 N-succinyl-Ala-Phe-Lys-7-amido-4-methylcoumarin pH 8.5 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens initiator of matrix-degrading protein cascade, activates hepatocyte growth factor scattering factor ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y5Y6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
milk
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hepatocyte growth factor + H2O
-
 Homo sapiens ?
-
 ?
additional information cleaves synthetic substrates with arginine or lysine as their P1 sites and prefers small side chain amino acids, such as Ala and Gly, at P2 sites Homo sapiens ?
-
 ?
additional information initiator of matrix-degrading protein cascade, activates hepatocyte growth factor scattering factor Homo sapiens ?
-
 ?
N-succinyl-Ala-Phe-Lys-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens N-succinyl-Ala-Phe-Lys + 7-amino-4-methylcoumarin
-
 ?
N-tert-butoxycarbonyl-gamma-benzyl-Glu-Ala-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens N-tert-butoxycarbonyl-gamma-benzyl-Glu-Ala-Arg + 7-amino-4-methylcoumarin
-
 ?
N-tert-butoxycarbonyl-gamma-benzyl-Glu-Gly-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens N-tert-butoxycarbonyl-gamma-benzyl-Glu-Gly-Arg + 7-amino-4-methylcoumarin
-
 ?
N-tert-butoxycarbonyl-Gln-Ala-Arg 7-amido-4-methylcoumarin + H2O
-
 Homo sapiens N-tert-butoxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin
-
 ?
N-tert-butoxycarbonyl-Leu-Gly-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens N-tert-butoxycarbonyl-Leu-Gly-Arg + 7-amino-4-methylcoumarin
-
 ?
plasminogen + H2O
-
 Homo sapiens ?
-
 ?
pro-urokinase plasminogen activator + H2O
-
 Homo sapiens ?
-
 ?