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Literature summary for 3.4.21.108 extracted from

  • Chung, H.J.; Jamal, M.A.H.M.; Hong, S.T.
    The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi (2020), Sci. Rep., 10, 5284.
    View publication on PubMed
Search for more literature for 3.4.21.108

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
ucf-101 specific inhibitor Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.002569
-
 oligomeric alpha-synuclein at pH 7.4 and 25°C Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
oligomeric alpha-synuclein + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA agarose column chromatography Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme does not affect monomeric alpha-synuclein Mus musculus ?
-
-
oligomeric alpha-synuclein + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
high-temperature requirement A2
-
 Mus musculus
HtrA2
-
 Mus musculus
HtrA2/Omi
-
 Mus musculus