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Literature summary for 3.4.21.108 extracted from

  • Singh, S.; Datta, G.; Jain, S.; Thakur, V.; Arora, P.; Muneer, A.; Asad, M.; Ali, S.; Mohmmed, A.
    Dual role of an essential HtrA2/Omi protease in the human malaria parasite Maintenance of mitochondrial homeostasis and induction of apoptosis-like cell death under cellular stress (2022), PLoS Pathog., 18, e1010932.
    View publication on PubMed
Search for more literature for 3.4.21.108

Inhibitors

Inhibitors Comment Organism Structure
ucf-101 specific inhibitor Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Plasmodium falciparum 5739
-

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum A0A143ZXD4
-
-

Subunits

Subunits Comment Organism
? x * 43000, hemagglutinin-fused protein, SDS-PAGE Plasmodium falciparum

Synonyms

Synonyms Comment Organism
high-temperature requirement A2
-
 Plasmodium falciparum
HtrA2
-
 Plasmodium falciparum
HtrA2/Omi
-
 Plasmodium falciparum

General Information

General Information Comment Organism
malfunction transient enzyme knock-down inhibits parasite growth, disrupts the intra-erythrocytic parasite cycle, and affects mitochondria development Plasmodium falciparum
physiological function the enzyme plays a dual role in maintenance of parasite mitochondria under normal conditions, as well as regulation of programmed cell death under cellular stress conditions. The enzyme activity is not essential for parasite survival Plasmodium falciparum