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Literature summary for 3.4.21.108 extracted from

  • Hammer, L.; Levin-Salomon, V.; Yaeli-Slonim, N.; Weiss, M.; Dekel-Bird, N.P.; Olender, T.; Porat, Z.; Winograd-Katz, S.; Savidor, A.; Levin, Y.; Bialik, S.; Geiger, B.; Kimchi, A.
    A new function for the serine protease HtrA2 in controlling radiation-induced senescence in cancer cells (2022), Mol. Oncol., 16, 1365-1383.
    View publication on PubMed
Search for more literature for 3.4.21.108

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
vimentin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
 Homo sapiens
-
NCI-H460 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
vimentin + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 36000, active enzyme, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
high-temperature requirement A2
-
 Homo sapiens
HtrA2
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme cleaves vimentin and affects vimentin assembly and polymerization following irradiation Homo sapiens
physiological function the enzyme is involved in the cytoskeletal reorganization that accompanies radiation-induced senescence and the continuous maintenance of proliferation arrest Homo sapiens