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Literature summary for 3.4.21.108 extracted from

  • Chaganti, L.K.; Dutta, S.; Kuppili, R.R.; Mandal, M.; Bose, K.
    Structural modeling and role of HAX-1 as a positive allosteric modulator of human serine protease HtrA2 (2019), Biochem. J., 476, 2965-2980.
    View publication on PubMed
Search for more literature for 3.4.21.108

Activating Compound

Activating Compound Comment Organism Structure
HAX-1 hematopoietic cell-specific protein 1-associated protein X-1, allosteric activator of the enzyme Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 (DE3) pLysS cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
HAX-1 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O43464
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-IDA affinity column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-casein + H2O
-
 Homo sapiens ?
-
 ?
HAX-1 + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
trimer 3 * 36000, mature enzyme, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
high-temperature requirement A2
-
 Homo sapiens
HtrA2
-
 Homo sapiens