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Literature summary for 3.4.21.108 extracted from
- cFLIP - An interacting partner and a novel substrate for pro-apoptotic serine protease HtrA2 (2024), Biochem. Biophys. Rep., 38, 101682.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S174A | catalytically inactive mutant | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O43464 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA column chromatography | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-casein + H2O | - |
Homo sapiens | ? | - |
? |  |
| cFLIP + H2O | cellular FLICE like inhibitory protein | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * about 40000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| high-temperature requirement A2 | - |
Homo sapiens |
| HtrA2 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme plays a crucial role in apoptosis by cleaving inhibitory and anti-apoptotic proteins by translocating from mitochondria to the cytosol | Homo sapiens |
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