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Literature summary for 3.4.21.108 extracted from

  • Gieldon, A.; Zurawa-Janicka, D.; Jarzab, M.; Wenta, T.; Golik, P.; Dubin, G.; Lipinska, B.; Ciarkowski, J.
    Distinct 3D architecture and dynamics of the human HtrA2(Omi) protease and its mutated variants (2016), PLoS ONE, 11, e0161526 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
structures of variant V226K/S306A and V325D. Upon binding of specific peptide ligand NH2-GWTMFWV-COOH, the PDZ domains open more dynamically in the wild type protease compared to the V226K mutant, whereas the movement is not observed in the V325D mutant. The movement relies on a PDZ vs. protease domain rotation which opens the protease domain-PDZ interface Homo sapiens

Protein Variants

Protein Variants Comment Organism
V226K increase in activtiy compared to weidl-type Homo sapiens
V226K/S306A inactive Homo sapiens
V325D inactive Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O43464
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