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Literature summary for 3.4.21.108 extracted from

  • Lucotte, B.; Tajhizi, M.; Alkhatib, D.; Samuelsson, E.; Wiehager, B.; Schedin-Weiss, S.; Sundstrom, E.; Winblad, B.; Tjernberg, L.; Behbahani, H.
    Stress conditions increase vimentin cleavage by Omi/HtrA2 protease in human primary neurons and differentiated neuroblastoma cells (2015), Mol. Neurobiol., 52, 1077-1092 .
    View publication on PubMed
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Application

Application Comment Organism
medicine HtrA2 under several different stress conditions induces cleavage of vimentin in wild-type as well as SH-SY5Y cells transfected with amyloid precursor protein with the Alzheimer disease-associated Swedish mutation. After stress treatment, inhibition of HtrA2 protease activity by the specific inhibitor, Ucf-101, reduces the cleavage of vimentin in wild-type cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ucf-101 specific inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O43464
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
neuron increased interaction between HtrA2 and vimentin in human primary neurons upon stress stimuli Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
vimentin + H2O
-
 Homo sapiens ?
-
 ?

General Information

General Information Comment Organism
physiological function HtrA2 under several different stress conditions induces cleavage of vimentin in wild-type as well as SH-SY5Y cells transfected with amyloid precursor protein with the Alzheimer disease-associated Swedish mutation. After stress treatment, inhibition of HtrA2 protease activity by the specific inhibitor, Ucf-101, reduces the cleavage of vimentin in wild-type cells Homo sapiens