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Literature summary for 3.4.21.108 extracted from

  • Winkler, J.; Rand, M.L.; Schmugge, M.; Speer, O.
    Omi/HtrA2 and XIAP are components of platelet apoptosis signalling (2013), Thromb. Haemost., 109, 532-539.
    View publication on PubMed
Search for more literature for 3.4.21.108

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol Omi/HtrA2 and Smac/Diablo are released from mitochondria into the platelet cytosol together with cytochrome c after induction of apoptosis by theCa2+ ionophore A23187 or the BH3 mimetic ABT-737, and to a lesser extent, after platelet stimulation with collagen and thrombin Homo sapiens 5829
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mitochondrion Omi/HtrA2 and Smac/Diablo are released from mitochondria into the platelet cytosol together with cytochrome c after induction of apoptosis by theCa2+ ionophore A23187 or the BH3 mimetic ABT-737, and to a lesser extent, after platelet stimulation with collagen and thrombin Homo sapiens 5739
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Organism

Organism UniProt Comment Textmining
Homo sapiens O43464
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Source Tissue

Source Tissue Comment Organism Textmining
blood platelet platelets contain the pro-apoptotic proteins Omi/HtrA2 and Smac/Diablo, as well as their target, the X-linked inhibitor of apoptosis XIAP Homo sapiens
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General Information

General Information Comment Organism
physiological function platelets contain the pro-apoptotic proteins Omi/HtrA2 and Smac/Diablo, as well as their target the X-linked inhibitor of apoptosis XIAP. Omi/HtrA2 and Smac/Diablo are released from mitochondria into the platelet cytosol together with cytochrome c after induction of apoptosis by theCa2+ ionophore A23187 or the BH3 mimetic ABT-737, and to a lesser extent, after platelet stimulation with collagen and thrombin Homo sapiens