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Literature summary for 3.4.21.108 extracted from

  • Sosna, J.; Voigt, S.; Mathieu, S.; Kabelitz, D.; Trad, A.; Janssen, O.; Meyer-Schwesinger, C.; Schuetze, S.; Adam, D.
    The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis (2013), Cell Commun. Signal., 11, 76.
    View publication on PubMed
Search for more literature for 3.4.21.108

Organism

Organism UniProt Comment Textmining
Mus musculus Q9JIY5
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Source Tissue

Source Tissue Comment Organism Textmining
NIH-3T3 cell
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 Mus musculus
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Synonyms

Synonyms Comment Organism
HtrA2/Omi
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 Mus musculus

General Information

General Information Comment Organism
physiological function pharmacological inhibition or genetic deletion of enzyme HtrA2/Omi protects from TNF-induced necroptosis. HtrA2/Omi does not cleave ubiquitin C-terminal hydrolase UCH-L1 during TNF-induced necroptosis, but rather induces monoubiquitination indicative for UCH-L1 activation. Correspondingly, pharmacologic or RNA interference-mediated inhibition of UCH-L1 protects from TNF-induced necroptosis Mus musculus