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Literature summary for 3.4.21.108 extracted from

  • Chien, J.
    WT1 as a substrate of HtrA2: A potential pathway for therapeutic targeting by HtrA proteases (2010), Future Oncol., 6, 1233-1235.
    View publication on PubMed
Search for more literature for 3.4.21.108

Application

Application Comment Organism
medicine HtrA2-mediated proteolysis of WT1 may directly contribute to the effect of cytotoxic drugs warrants Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Wilms' tumor suppressor protein WT1 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Wilms' tumor suppressor protein WT1 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
high temperature requirement A2 protease
-
 Homo sapiens
HtrA2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function HtrA2 acts as an apoptotic factor which targets inhibitors of apoptosis during apoptosis, and thereby enhances caspase activation and caspase-mediated cell death Homo sapiens