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Literature summary for 3.4.21.108 extracted from

  • Essafi, A.; Hastie, N.D.
    WT1 the oncogene: a tale of death and HtrA (2010), Mol. Cell, 37, 153-155.
    View publication on PubMed
Search for more literature for 3.4.21.108

Inhibitors

Inhibitors Comment Organism Structure
UCF101
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion HtrA2 is a mitochondrial protease Homo sapiens 5739
-
nucleus HtrA2 is also present at low levels in the nucleus Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Wilms' tumor suppressor 1 + H2O Homo sapiens bona fide substrate for HtrA2-mediated proteolysis, cleavage sites are in the C terminus at Val286 and Leu320, resulting in fragments of 20000 and 35000 Da, respectively, while another cleavage site is in the N terminus at Leu91 adjacent to suppression domain ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Wilms' tumor suppressor 1 + H2O bona fide substrate for HtrA2-mediated proteolysis, cleavage sites are in the C terminus at Val286 and Leu320, resulting in fragments of 20000 and 35000 Da, respectively, while another cleavage site is in the N terminus at Leu91 adjacent to suppression domain Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
high temperature requirement protein A2
-
 Homo sapiens
HtrA2/Omi
-
 Homo sapiens