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Literature summary for 3.4.21.108 extracted from

  • Wang, C.Y.; Lin, Y.S.; Su, W.C.; Chen, C.L.; Lin, C.F.
    Glycogen synthase kinase-3 and Omi/HtrA2 induce annexin A2 cleavage followed by cell cycle inhibition and apoptosis (2009), Mol. Biol. Cell, 20, 4153-4161.
    View publication on PubMed
Search for more literature for 3.4.21.108

Inhibitors

Inhibitors Comment Organism Structure
ucf-101 treatment of lung epithelial adenocarcinoma cell A549 decreases the cleavage of annexin A2 under both serum withdrawal and cisplatin treatment Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol Omi/HtrA2 relocates from mitochondria to the cytosol in lung adenocarcinoma cell line A549 under serum withdrawal Homo sapiens 5829
-
mitochondrion immunostaining and confocal microscopy shows that Omi/HtrA2 is located primarily in the mitochondria of lung adenocarcinoma cell line A549 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung adenocarcinoma cell line human lung epithelial adenocarcinoma cell A549 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
X-linked inhibitor of apoptosis protein + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Omi/HtrA2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens Omi/HtrA2 siRNA decreases the cleavage of annexin A2 lung epithelial adenocarcinoma cell A549 under both serum withdrawal and cisplatin treatment down

General Information

General Information Comment Organism
physiological function Omi/HtrA2 is released from mitochondria to the cytosol and is required for annexin A2 cleavage under apoptotic stimuli Homo sapiens