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Literature summary for 3.4.21.108 extracted from

  • Balakrishnan, M.P.; Cilenti, L.; Mashak, Z.; Popat, P.; Alnemri, E.S.; Zervos, A.S.
    THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death (2009), Am. J. Physiol. Heart Circ. Physiol., 297, H643-H653.
    View publication on PubMed
Search for more literature for 3.4.21.108

Cloned(Commentary)

Cloned (Comment) Organism
expressed in yeast as a bait protein in a two-hybrid assay and by transient transfection of Human embryonic kidney (HEK)-293 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ucf-101
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thanatos-associated protein 5 (THAP5) + H2O Homo sapiens in a yeast two-hybrid assay it is shown that Omi/HtrA2 protease interacts with thanatos-associated protein 5. Degradation assays show that thanatos-associated protein 5 is cleaved by Omi/HtrA2 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thanatos-associated protein 5 (THAP5) + H2O in a yeast two-hybrid assay it is shown that Omi/HtrA2 protease interacts with thanatos-associated protein 5. Degradation assays show that thanatos-associated protein 5 is cleaved by Omi/HtrA2 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Omi/HtrA2 protease
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function Omi/HtrA2 interacts with thanatos-associated protein 5 in mammalian cells during apoptosis Homo sapiens