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Literature summary for 3.4.21.108 extracted from

  • McCormick, A.L.; Roback, L.; Mocarski, E.S.
    HtrA2/Omi terminates cytomegalovirus infection and is controlled by the viral mitochondrial inhibitor of apoptosis (vMIA) (2008), PLoS Pathog., 4, e1000063.
    View publication on PubMed
Search for more literature for 3.4.21.108

Activating Compound

Activating Compound Comment Organism Structure
additional information HtrA2/Omi levels rise dramatically within mitochondria at late times during infection with cytomegalovirus Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
into pDNA3.1+ Homo sapiens

Protein Variants

Protein Variants Comment Organism
S306A catalytic site mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-[5-(2-nitrophenyl)furfuryliodine]1,3-diphenyl-2-thiobarbituric acid UCF-101 Homo sapiens
TLCK
-
 Homo sapiens
viral mitochondrial inhibitor of apoptosis vMIA Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
 HtrA2, determined by SDS-PAGE and Western Blot analysis Homo sapiens
49000
-
 pro-HtrA2, determined by SDS-PAGE and Western Blot analysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O43464
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
HtrA2/Omi
-
 Homo sapiens
serine protease
-
 Homo sapiens