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Literature summary for 3.4.21.108 extracted from

  • Chao, J.R.; Parganas, E.; Boyd, K.; Hong, C.Y.; Opferman, J.T.; Ihle, J.N.
    Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons (2008), Nature, 452, 98-102.
    View publication on PubMed
Search for more literature for 3.4.21.108

Protein Variants

Protein Variants Comment Organism
HtrA2DELTA134-349 mutant, deletion of protease domain, no interaction with Hax1 Mus musculus
HtrA2DELTAMTS mutant, deletion of MTS domain, weaker interaction with Hax1 detected Mus musculus
HtrA2DELTAMTS-PDZ mutant, deletion of MTS and PDZ domain, weaker interaction with Hax1 detected Mus musculus
HtrA2DELTAPDZ mutant, deletion of PDZ domain, strong interaction with Hax1 detected Mus musculus
HtrA2S306A inactive mutant Mus musculus
HtrA2_350-458 mutant, PDZ domain, no interaction with Hax1 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-
mitochondrial intermembrane space
-
 Mus musculus 5758
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
 processed HtrA2, determined by SDS-PAGE and Western Blot analysis Mus musculus
50000
-
 unprocessed HtrA2, determined by SDS-PAGE and Western Blot analysis Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
mitochondrial and cytosolic fractions are prepared Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte
-
 Mus musculus
-
neuron
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
HtrA2
-
 Mus musculus
Omi
-
 Mus musculus