Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.108 extracted from

  • Bhuiyan, M.S.; Fukunaga, K.
    Mitochondrial serine protease HtrA2/Omi as a potential therapeutic target (2009), Curr. Drug Targets, 10, 372-383.
    View publication on PubMed
Search for more literature for 3.4.21.108

Application

Application Comment Organism
medicine HtrA2 is linked to cancer and neurodegeneration, like Alzheimers disease, Parkinsons disease, Huntingtons disease, and brain, kidney and myocardial ischemia, reperfusion Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-[5-(2-nitrophenyl)furfuryliodine]1,3-diphenyl-2-thiobarbituric acid UCF-101 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol released into the cytosol upon apoptotic stimuli Homo sapiens 5829
-
mitochondrial intermembrane space
-
 Homo sapiens 5758
-
mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
 cleaved, activated form Homo sapiens
50000
-
 precursor HtrA2 Homo sapiens
110000
-
 trimer, determined by gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-casein + H2O
-
 Homo sapiens ?
-
 ?
amyloid precursor protein + H2O APP Homo sapiens ?
-
 ?
Apollon + H2O BRUCE-apollon Homo sapiens ?
-
 ?
beta-casein + H2O
-
 Homo sapiens ?
-
 ?
Fas-Fas L + H2O
-
 Homo sapiens ?
-
 ?
FLIP + H2O Fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein Homo sapiens ?
-
 ?
glycoprotein alpha1 + H2O
-
 Homo sapiens ?
-
 ?
HS1-associated protein X1 + H2O HAX-1 Homo sapiens ?
-
 ?
hyaluronidase + H2O
-
 Homo sapiens ?
-
 ?
inhibitor of apoptosis + H2O IAP Homo sapiens ?
-
 ?
PED-PEA 15 + H2O death effector domain-containing protein Homo sapiens ?
-
 ?
WARTS kinase + H2O WARTS, WTS, large tumor-suppressor 1 mitotic kinase Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
homotrimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
high temperature requirement A2
-
 Homo sapiens
serine protease HtrA2/Omi
-
 Homo sapiens