Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.108 extracted from

  • Marabese, M.; Mazzoletti, M.; Vikhanskaya, F.; Broggini, M.
    HtrA2 enhances the apoptotic functions of p73 on bax (2008), Cell Death Differ., 15, 849-858.
    View publication on PubMed
Search for more literature for 3.4.21.108

Application

Application Comment Organism
medicine the relation between p73 and HtrA2 may help to understand the behavior of the p73 protein in the responses of cancer cells to chemotherapy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
into the vector pCMV/SPORT Homo sapiens

Protein Variants

Protein Variants Comment Organism
S306A proteolytically inactive mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
HtrA2 siRNA
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion healthy cell Homo sapiens 5739
-
nucleus following apoptotic stimuli, HtrA2 accumulates in the nucleus Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens HtrA2 cleaves p73alpha in the C-terminal portion ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
 Homo sapiens
-
NCI-H1299 cell human non-small-cell lung carcinoma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information HtrA2 cleaves p73alpha in the C-terminal portion Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
HtrA2
-
 Homo sapiens
serine protease
-
 Homo sapiens