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Literature summary for 3.4.21.108 extracted from
- The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila (2008), Cell Death Differ., 15, 1073-1083.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| constructs encoding C-terminal His6-tagged full-length dOmi or truncated mutants are generated using the pET-21a and the pVL-1393 transfer vector, proteins are overexpressed in Escherichia coli BL21DE3 and Sf9 insect cells, respectively | Drosophila melanogaster |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | released into the cytosol during apoptosis | Drosophila melanogaster | 5829 | - |
| mitochondrial intermembrane space | - |
Drosophila melanogaster | 5758 | - |
| mitochondrion | - |
Drosophila melanogaster | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 33000 | - |
dOmi-S, determined by SDS-PAGE and Western Blot analysis | Drosophila melanogaster |
| 35000 | - |
dOmi-L, determined by SDS-PAGE and Western Blot analysis | Drosophila melanogaster |
| 38000 | - |
unprocessed dOmi, determined by SDS-PAGE and Western Blot analysis | Drosophila melanogaster |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Drosophila melanogaster | cleavage of DIAP1 between the BIR1 and BIR2 domain and further degradation of BIR1 | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | Q9VFJ3 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Drosophila melanogaster |
| ubiquitination | - |
Drosophila melanogaster |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| using TALON agarose | Drosophila melanogaster |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| eye | eye disc | Drosophila melanogaster | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | cleavage of DIAP1 between the BIR1 and BIR2 domain and further degradation of BIR1 | Drosophila melanogaster | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dOmi/HtrA2 | two isoforms, dOmi-L, dOmi-S | Drosophila melanogaster |
| Omi/HtrA2 | - |
Drosophila melanogaster |
| Omi/HtrA2 serine protease | - |
Drosophila melanogaster |
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