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Literature summary for 3.4.21.108 extracted from

  • Bhuiyan, M.S.; Fukunaga, K.
    Activation of HtrA2, a mitochondrial serine protease mediates apoptosis: current knowledge on HtrA2 mediated myocardial ischemia/reperfusion injury (2008), Cardiovasc. ther., 26, 224-232.
    View publication on PubMed
Search for more literature for 3.4.21.108

Application

Application Comment Organism
medicine therapeutic interventions that inhibit HtrA2 expression, translocation, or protease activity may provide attractive therapeutics in the treatment of cardiovascular diseases Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-[5-(2-nitrophenyl)furfuryliodine]1,3-diphenyl-2-thiobarbituric acid UCF-101 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol translocation from mitochondria to cytosol Homo sapiens 5829
-
mitochondrion translocation from mitochondria to cytosol Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
 predicted Homo sapiens
110000
-
 determined by gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiac myocyte
-
 Homo sapiens
-
heart
-
 Homo sapiens
-

Subunits

Subunits Comment Organism
homotrimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
high temperature requirement A2 serine protease
-
 Homo sapiens
HtrA2
-
 Homo sapiens
HtrA2 serine protease
-
 Homo sapiens
HtrA2/Omi
-
 Homo sapiens