Literature summary for 3.4.21.108 extracted from

Plun-Favreau, H.; Gandhi, S.; Wood-Kaczmar, A.; Deas, E.; Yao, Z.; Wood, N.W.
What have PINK1 and HtrA2 genes told us about the role of mitochondria in Parkinsons disease? (2008), Ann. N. Y. Acad. Sci., 1147, 30-36.

Search for more literature for 3.4.21.108

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	phosphorylation	Homo sapiens

Application

Application	Comment	Organism
medicine	the identification of the role of HtrA2 in neurodegeneration will lead to an improved understanding of the pathogenesis of Parkinsons disease	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
A141S	polymorphism associated with Parkinsons disease	Homo sapiens
G399S	heterozygous mutation identified in Parkinsons disease patients	Homo sapiens
S142D	recombinant HtrA2 mutant, produced to determine whether HtrA2 phosphorylation affects its proteolytic activity	Homo sapiens
S400D	recombinant HtrA2 mutant, produced to determine whether HtrA2 phosphorylation affects its proteolytic activity	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
35000	-	determined by SDS-PAGE and Western Blot analysis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	Ser142 and Ser400	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
HtrA2	-	Homo sapiens

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Release 2026.1 (March 2026)