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Literature summary for 3.4.21.108 extracted from
- GRIM-19 associates with the serine protease HtrA2 for promoting cell death (2007), Oncogene, 26, 4842-4849.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| GRIM-19 | direct enhancement of HtrA2 activity in vitro. HtrA2-driven destruction of the antiapoptotic X-linked inhibitor of apoptosis protein is augmented | Homo sapiens | |
| IFN/all-trans retinoic acid | enhances interaction of GRIM-19 with HtrA2. Causes a concurrent release of HtrA2 and GRIM-19 from mitochondria | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | critical role of HtrA2 in a cytokine-induced cell death response. Inhibition by a viral protein | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| coexpression of Flag-tagged and Ndelta133 HtrA2 proteins and a myc-epitope-tagged GRIM-19 protein in MCF-7 cells. MCF-7 cells transfected with expression vectors coding for GFP-HtrA2 and GFP-HtrA2-S306A and GRIM-19 | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S306A | catalytically inactive | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| antisense HtrA2 | significantly inhibits IFN/all-trans retinoic acid-induced degradation of X-linked inhibitor of apoptosis protein | Homo sapiens | |
| vIRF1 | human herpes virus-8 (HHV-8)-coded oncoprotein, disrupts interactions of GRIM-19 with HtrA2 | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MCF-7 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| X-linked inhibitor of apoptosis protein + H2O | - |
Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| serine protease HtrA2 | - |
Homo sapiens |
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