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Literature summary for 3.4.21.108 extracted from
- The serine protease Omi/HtrA2 is involved in XIAP cleavage and in neuronal cell death following focal cerebral ischemia/reperfusion (2007), Neurochem. Int., 50, 172-180.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | focal cerebral ischemia/reperfusion induces a mitochondrial up-regulation of Omi/HtrA2 and significantly increases cytosolic accumulation of Omi/HtrA2 | Rattus norvegicus |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | Omi/HtrA2 is involved in neuronal cell death following focal cerebral ischemia/reperfusion. Blocking the proteolytic activity of Omi/HtrA2 with specific inhibitors, such as the ucf-101, may be a way to afford neuroprotection and minimize cellular damage in cerebral ischemia/reperfusion | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ucf-101 | specific inhibitor of Omi/HtrA2. Reduces the number of TUNEL-positive cells, attenuates the X-linked inhibitor of apoptosis protein-breakdown and reduces the infarct size | Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | focal cerebral ischemia in rats results in Omi/HtrA2 translocation from the mitochondria to the cytosol | Rattus norvegicus | 5829 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| neuron | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| X-linked inhibitor of apoptosis protein + H2O | - |
Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Omi/HtrA2 | - |
Rattus norvegicus |
| serine protease Omi/HtrA2 | - |
Rattus norvegicus |
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