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Literature summary for 3.4.21.108 extracted from

  • Liu, M.L.; Liu, M.J.; Kim, J.M.; Kim, H.J.; Kim, J.H.; Hong, S.T.
    HtrA2 interacts with A beta peptide but does not directly alter its production or degradation (2005), Mol. Cell, 20, 83-89.
    View publication on PubMed
Search for more literature for 3.4.21.108

Application

Application Comment Organism
medicine involvement of HtrA2 in the etiology of Alzheimer's disease Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
subcloned into pET28a and propageted in Escherichia coli DH5alpha, expressed in Escherichia coli BL21 (DE3) pLys, overexpression in K269 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion mainly localized Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme by ProBondTM resin Homo sapiens

Storage Stability

Storage Stability Organism
-80°C, phosphate buffered saline, pH 7.4, 20% glycerol Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
A beta 40 HtrA2/Omi binds preferentially to the short form of A beta peptides, the enzyme does not perform degradation by direct hydrolysis Homo sapiens ?
-
 ?
A beta 42 HtrA2/Omi binds poorly to A beta 42, the enzyme does not perform degradation by direct hydrolysis Homo sapiens ?
-
 ?
alpha-secretase peptide HtrA2/Omi does not perform degradation by direct hydrolysis Homo sapiens ?
-
 ?
beta-secretase peptide HtrA2/Omi does not perform degradation by direct hydrolysis Homo sapiens ?
-
 ?
casein + H2O strong hydrolytic activity Homo sapiens ?
-
 ?
gamma-secretase peptide HtrA2/Omi binds less strongly to gamma-secretase substrate peptide as compared to alpha-secretase substrate peptide and beta-secretase substrate peptide, the enzyme does not perform degradation by direct hydrolysis Homo sapiens ?
-
 ?
additional information does not bind the reversed control peptide A beta 41-1 and peptide H2-Opt Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
HtrA2/Omi
-
 Homo sapiens