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Literature summary for 3.4.21.108 extracted from

  • Trencia, A.; Fiory, F.; Maitan, M.A.; Vito, P.; Barbagallo, A.P.; Perfetti, A.; Miele, C.; Ungaro, P.; Oriente, F.; Cilenti, L.; Zervos, A.S.; Formisano, P.; Beguinot, F.
    Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15 (2004), J. Biol. Chem., 279, 46566-46572.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information UV irradiation leads to an almost complete disappearance of mitochondrial Omi/HtrA2 and a parallel appearance of Omi/HtrA2 in the cytoplasm, induction of Omi/HtrA2 binding to ped/pea-15 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in HeLa cells and HEK-293 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ucf-101 inhibits degradation of endogenous ped/pea-15 by Omi/HtrA2 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
kidney from embryos Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ped/pea-15 HtrA2 is a specific interactor of the ped/pea-15 death effector domain and leads to its degradation Homo sapiens ?
-
 ?
X-linked inhibitor of apoptosis protein + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Omi/HtrA2
-
 Homo sapiens
serine protease
-
 Homo sapiens