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Literature summary for 3.4.21.108 extracted from
- The C-terminal tail of presenelin regulates Omi/HtrA2 protease activity (2004), J. Biol. Chem., 279, 45844-45854.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli and MEF cells from mnd2 mouse | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| L286V | Alzheimer mutant presenilin-1 | Homo sapiens |
| M146V | Alzheimer mutant presenilin-1 | Homo sapiens |
| S276C | deletion of the PDZ domain of Omi/HtrA2 | Homo sapiens |
| S306A | catalytically inactive Omi/HtrA2 | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293 cell | - |
Homo sapiens | - |
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 35S-beta-casein + H2O | C-terminus of presenilin-1 interacts the PDZ domain of with Omi/HtrA2, increasing its activity | Homo sapiens | ? | - |
? |  |
| c-inhibitor of apoptosis protein1 + H2O | C-terminus of presenilin-1 interacts with the PDZ domain of Omi/HtrA2, increasing its activity | Homo sapiens | ? | - |
? | |
| c-inhibitor of apoptosis protein2 + H2O | C-terminus of presenilin-1 interacts with the PDZ domain of Omi/HtrA2, increasing its activity | Homo sapiens | ? | - |
? | |
| X-linked inhibitor of apoptosis protein + H2O | C-terminus of presenilin-1 interacts with the PDZ domain of Omi/HtrA2, increasing its activity | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Omi/HtrA2 | - |
Homo sapiens |
| serine protease | - |
Homo sapiens |
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