Activating Compound | Comment | Organism | Structure |
---|---|---|---|
L-phenylalanine | essential for the formation of a homotrimer and for the HtrA2 serine protease activity | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of GST-HtrA2 delta 133 proteins in Escherichia coli BL21 from GST-HTRA2 delta 133 WT, S306 and F149D constructs | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
63000 | - |
most of the purified GST-HtrA2 delta 133 proteins | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
rapid purification of GST-HtrA2 delta 133 proteins on glutathione-Sepharose 4B beads | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | embryonic kindey 293 cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(35S) Met-labeled proteolytically inactive S306 form of full length HtrA2 + H2O | - |
Homo sapiens | ? | - |
? | |
beta-casein + H2O | - |
Homo sapiens | ? | - |
? | |
X-linked inhibitor of apoptosis protein + H2O | homotrimeric structure of enzyme is required for executing its activity | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
trimer | homotrimer, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
HtrA2 | - |
Homo sapiens |
serine protease | - |
Homo sapiens |